Justin connected off of Philadelphia Phillies starter Kyle Kendrick in the second inning, his ninth of the season.
Then a few minutes later, B.J. came to bat against Tommy Hunter of the Baltimore Orioles in the fourth inning and hit his 10th home run of the season.
The Uptons are not the first brothers to have 100 career home runs in the major leagues.
And there is one more pair of brothers, can you tell us who they are?