Head to Head Analysis: Horizon Therapeutics (NASDAQ:HZNP) versus Dicerna Pharmaceuticals (NASDAQ:DRNA)

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Horizon Therapeutics (NASDAQ:HZNP) and Dicerna Pharmaceuticals (NASDAQ:DRNA) are both medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their analyst recommendations, earnings, dividends, institutional ownership, risk, profitability and valuation.

Insider & Institutional Ownership

87.8% of Horizon Therapeutics shares are owned by institutional investors. Comparatively, 85.8% of Dicerna Pharmaceuticals shares are owned by institutional investors. 4.1% of Horizon Therapeutics shares are owned by company insiders. Comparatively, 19.9% of Dicerna Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Profitability

This table compares Horizon Therapeutics and Dicerna Pharmaceuticals’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Horizon Therapeutics 3.79% 33.57% 9.04%
Dicerna Pharmaceuticals -1,284.93% -52.17% -29.37%

Earnings & Valuation

This table compares Horizon Therapeutics and Dicerna Pharmaceuticals’ revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Horizon Therapeutics $1.21 billion 3.59 -$74.19 million $1.83 12.82
Dicerna Pharmaceuticals $6.18 million 156.98 -$88.85 million ($1.20) -11.83

Horizon Therapeutics has higher revenue and earnings than Dicerna Pharmaceuticals. Dicerna Pharmaceuticals is trading at a lower price-to-earnings ratio than Horizon Therapeutics, indicating that it is currently the more affordable of the two stocks.

Analyst Ratings

This is a breakdown of recent ratings and price targets for Horizon Therapeutics and Dicerna Pharmaceuticals, as reported by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Horizon Therapeutics 0 2 9 0 2.82
Dicerna Pharmaceuticals 0 0 8 0 3.00

Horizon Therapeutics currently has a consensus target price of $31.91, indicating a potential upside of 36.01%. Dicerna Pharmaceuticals has a consensus target price of $22.57, indicating a potential upside of 58.95%. Given Dicerna Pharmaceuticals’ stronger consensus rating and higher probable upside, analysts plainly believe Dicerna Pharmaceuticals is more favorable than Horizon Therapeutics.

Risk & Volatility

Horizon Therapeutics has a beta of 1.03, indicating that its stock price is 3% more volatile than the S&P 500. Comparatively, Dicerna Pharmaceuticals has a beta of 2.28, indicating that its stock price is 128% more volatile than the S&P 500.

Summary

Horizon Therapeutics beats Dicerna Pharmaceuticals on 8 of the 13 factors compared between the two stocks.

About Horizon Therapeutics

Horizon Therapeutics Public Limited Company, a biopharmaceutical company, focuses on researching, developing, and commercializing medicines that address unmet treatment needs for rare and rheumatic diseases in the United States and internationally. Its orphan and rheumatology marketed medicines include KRYSTEXXA, a medicine for the treatment of uncontrolled gout; RAVICTI for use as a nitrogen-binding agent for chronic management of adult and pediatric patients; PROCYSBI for nephropathic cystinosis, a rare and life-threatening metabolic disorder; ACTIMMUNE for chronic granulomatous disease; RAYOS for the treatment of multiple conditions, rheumatoid arthritis; BUPHENYL tablets for oral administration and BUPHENYL powder for oral, nasogastric, or gastrostomy tube administration; and QUINSAIR, a formulation of the antibiotic drug levofloxacin for the management of chronic pulmonary infections due to Pseudomonas aeruginosa in adult patients with cystic fibrosis. The company's primary care marketed medicines comprise PENNSAID 2% that is indicated for the treatment of pain of osteoarthritis of the knees; DUEXIS for the relief of signs and symptoms of RA and OA, and to decrease the risk of developing upper-GI ulcers; VIMOVO for the relief of signs and symptoms of OA, RA, and AS and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers; and MIGERGOT, a therapy to abort or prevent vascular headaches, such as migraines and migraine variants. It has collaboration agreements with Alliance for Lupus Research, Syneos Health, Inc., and HemoShear Therapeutics, LLC. The company was formerly known as Horizon Pharma Public Limited Company and changed its name to Horizon Therapeutics Public Limited Company in May 2019. Horizon Therapeutics Public Limited Company was founded in 2005 and is headquartered in Dublin, Ireland.

About Dicerna Pharmaceuticals

Dicerna Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery and development of ribonucleic acid interference (RNAi)-based pharmaceuticals. The company develops pharmaceuticals using its GalXC RNAi platform for the treatment of diseases involving the liver, including rare diseases, viral infectious diseases, chronic liver diseases, and cardiovascular diseases. Its principal development programs include DCR-PHXC for the treatment of primary hyperoxaluria; DCR-HBVS for the treatment of chronic hepatitis B virus infection; and a program for an undisclosed rare liver disease. The company's development programs also comprise additional rare disease programs; a program for the treatment of hypercholesterolemia; and various programs in various therapeutic areas involving liver function. The company has strategic collaborations with Eli Lilly and Company, Alexion Pharmaceuticals, Inc., and Boehringer Ingelheim International GmbH. Dicerna Pharmaceuticals, Inc. was founded in 2006 and is headquartered in Cambridge, Massachusetts.

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