Sean Nolin started his first game in the major leagues for the Toronto Blue Jays and lasted an inning and a third surrendering six earned runs and seven hits.
Nolin lost for the first time since Aug. 27, 2011, when he was pitching for Class A Lansing.
Chris Davis launched his major league-leading 16th home run and the Baltimore Orioles scored nine runs in the first three innings to beat the Blue Jays 10-6.
Nick Markakis had three hits and three RBI and J.J. Hardy, Danny Valencia and Adam Jones all hit home runs for Baltimore, who lead all of baseball with 66 home runs this season.
Melky Cabrera, Brett Lawrie and Adam Lind all hit solo homers for the Blue Jays.